The stage is set during the 19th century London, in its capital where a wall divides the east and west of the Kingdom of Albion. Five high school girls, who enrolled in the prestigious Queens May Fair School, are involved in spy activities that involve disguise, infiltration, car chase, and more. These girls take advantage of their special abilities and fly around the shadow world.
Justice, and the enforcement of it, has changed. In the 22nd century, Japan enforces the Sibyl System, an objective means of determining the threat level of each citizen by examining their mental state for signs of criminal intent, known as their Psycho-Pass. Inspectors uphold the law by subjugating, often with lethal force, anyone harboring the slightest ill-will; alongside them are Enforcers, jaded Inspectors that have become latent criminals, granted relative freedom in exchange for carrying out the Inspectors' dirty work. Into this world steps Akane Tsunemori, a young woman with an honest desire to uphold justice. However, as she works alongside veteran Enforcer Shinya Kougami, she soon learns that the Sibyl System's judgments are not as perfect as her fellow Inspectors assume. With everything she has known turned on its head, Akane wrestles with the question of what justice truly is, and whether it can be upheld through the use of a system that may already be corrupt.
A year and a half after the events of the original sci-fi psychological thriller, Akane Tsunemori continues her work as an inspector—enforcing the Sibyl System's judgments. Joining her are new enforcers and junior inspector Mika Shimotsuki, a young woman blindly and inflexibly loyal to Sibyl. As Akane ponders both the nature of her job and the legitimacy of Sibyl's verdicts, a disturbing new menace emerges. A mysterious figure has discovered a way to control the Crime Coefficient—a number compiled from mental scans that allows Sibyl to gauge psychological health and identify potential criminals. Through these means, he is able to murder an enforcer, leaving behind a cryptic clue: "WC?" scrawled in blood on a wall. Akane and the rest of Division 1 soon find themselves playing a deadly game against their new foe, coming face-to-face with a conspiracy threatening not only the authority of the Sibyl System, but the very foundation of Akane's own convictions.